The game is set in 2027, 25 years before the first game and 45 years before the second game, at a time when multinational corporations have grown in power beyond the control of national governments. The game follows Adam Jensen, the newly hired security manager at Sarif Industries, a growing biotechnology firm. After terrorists brutally attack Sarif's Detroit-based headquarters, the mortally wounded Jensen is forced to undergo radical life-saving surgeries that replace large areas of his body with advanced prostheses and internal organ systems. Returning to work, he becomes embroiled in the global politics of the human enhancement movement in the search for those responsible for the attack.
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